PIN1 Antikörper (N-Term)

Produktnummer ABIN320389

Produktdetails anti-PIN1 Antikörper

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Bindungsspezifität: AA 1-163, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Aufreinigung: Protein-G affinity chromatography

Immunogen: Recombinant human Pin1 (1-163 aa) purified from E. coli

Klon: 3G8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1/500-1/1,000, recommended starting dilution 1/500).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 with 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Haltbarkeit: 12 months

Details zu PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Andere Bezeichnung: PIN1 (PIN1 Produkte)

Synonyme: DOD antikoerper, UBL5 antikoerper, dod antikoerper, ubl5 antikoerper, pin1 antikoerper, pin1a antikoerper, 0610025L01Rik antikoerper, D9Bwg1161e antikoerper, pin1b antikoerper, zgc:73206 antikoerper, PPIase pin1 antikoerper, MdPin1 antikoerper, Pin1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antikoerper, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antikoerper, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antikoerper, peptidyl-prolyl cis-trans isomerase Pin1 antikoerper, PIN1 antikoerper, Pin1 antikoerper, pin1 antikoerper, pin1.S antikoerper, pin1.L antikoerper, ppiD antikoerper, PITG_11123 antikoerper, LOC103419188 antikoerper

Hintergrund: Human Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.Synonyms: PIN-1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1

UniProt: Q13526