SH2B3 Antikörper (N-Term)

Produktnummer ABIN318699

Produktdetails anti-SH2B3 Antikörper

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SH2B3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody recognises an epitope within the N-terminal region (NT) of lymphocyte adaptor protein (LNK).

Aufreinigung: Antisera to LNK (NT) were raised by repeated immunisation of Goat with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen: Peptide sequence NGPALQPSSPC from LNK amino-terminus.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.3 - 1.0g/mL, detects a band of approximately 70 kDa in human MOLT4 celllysates. (Predicted Mwt.63.0 kDa)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5mg/mL

Buffer: TRIS buffered saline containing 0.02 % Sodium Azide and 0.5 % Bovine Serum Albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SH2B3

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Andere Bezeichnung: SH2B3 (SH2B3 Produkte)

Synonyme: LNK antikoerper, IDDM20 antikoerper, AI429800 antikoerper, Lnk antikoerper, SH2B adaptor protein 3 antikoerper, SH2B3 antikoerper, Sh2b3 antikoerper

Hintergrund: LNK is an SH2-containing adaptor protein, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis. LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFalpha. The role of LNK as a negative regulator, includes the down regulation of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFalpha, modulation of P13-kinase and MAPK ERK1/2 activity, and negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines.Synonyms: LNK, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, SH2B adapter protein 3, SH2B3, Signal transduction protein Lnk

Gen-ID: 10019

NCBI Accession: NP_005466

UniProt: Q9UQQ2