DCT Antikörper

Produktnummer ABIN317917

Produktdetails anti-DCT Antikörper

Target: DCT (Dopachrome Tautomerase (DCT))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: TRP2 antibody detects endogenous levels of TRP2 protein.(region surrounding Lys89)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DCT

Target: DCT (Dopachrome Tautomerase (DCT))

Andere Bezeichnung: TYRP2 / DCT (DCT Produkte)

Synonyme: TYRP2 antikoerper, RGD1564975 antikoerper, trp2 antikoerper, DT antikoerper, TRP-2 antikoerper, TRP2 antikoerper, Tyrp-2 antikoerper, Tyrp2 antikoerper, slaty antikoerper, slt antikoerper, zgc:109860 antikoerper, dopachrome tautomerase antikoerper, dopachrome tautomerase L homeolog antikoerper, DCT antikoerper, Dct antikoerper, dct antikoerper, dct.L antikoerper

Hintergrund: Tyrosinase (TYR), a type I membrane protein and copper-containing enzyme,is involved in the production of melanin, the primary pigment found in vertebrates.Melanin biogenesis requires the enzymatic activity of TYR, which catalyzes the critical and rate-limiting step of tyrosine hydroxylation in the biosynthesis of melanin. Defects effecting TYR activity result in various forms of albinism. The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.Synonyms: L-dopachrome Delta-isomerase, L-dopachrome tautomerase, TRP-2, TRP2, Tyrosinase-related protein 2

Molekulargewicht: approx. 60 kDa

Gen-ID: 1638

NCBI Accession: NP_001913

UniProt: P40126