GORASP2 Antikörper

Produktnummer ABIN317911

Produktdetails anti-GORASP2 Antikörper

Target: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GORASP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: GRASP55 antibody detects endogenous levels of GRASP55 protein.(region surrounding Leu215)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GORASP2

Target: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Andere Bezeichnung: GORASP2 / GOLPH6 (GORASP2 Produkte)

Synonyme: MGC53281 antikoerper, MGC132131 antikoerper, MGC73072 antikoerper, zgc:73072 antikoerper, DKFZp459O1715 antikoerper, 0610011A07Rik antikoerper, 2410043M02Rik antikoerper, 5730520M13Rik antikoerper, 9430094F20Rik antikoerper, AW552058 antikoerper, GOLPH2 antikoerper, GRASP55 antikoerper, GRS2 antikoerper, p59 antikoerper, Grs2 antikoerper, GOLPH6 antikoerper, golgi reassembly stacking protein 2 L homeolog antikoerper, golgi reassembly stacking protein 2 antikoerper, gorasp2.L antikoerper, gorasp2 antikoerper, GORASP2 antikoerper, CC1G_02936 antikoerper, Gorasp2 antikoerper

Hintergrund: The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65. GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi cisternae. The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure. ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis.Synonyms: GRS2, Golgi marker, Golgi phosphoprotein 6, Golgi reassembly-stacking protein 2, Golgi reassembly-stacking protein of 55 kDa, p59

Molekulargewicht: approx. 47 kDa

Gen-ID: 26003

NCBI Accession: NP_056345

UniProt: Q9H8Y8