GFRA4 Antikörper

Produktnummer ABIN317910

Produktdetails anti-GFRA4 Antikörper

Target: GFRA4 (GDNF Family Receptor alpha 4 (GFRA4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: GFRα-4 antibody detects endogenous levels of GFRα-4 protein.(region surrounding Pro178)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GFRA4

Target: GFRA4 (GDNF Family Receptor alpha 4 (GFRA4))

Andere Bezeichnung: GFRA4 / GDNFR-alpha 4 (GFRA4 Produkte)

Synonyme: zgc:171814 antikoerper, AW060733 antikoerper, G630015H18Rik antikoerper, GDNF family receptor alpha 4 antikoerper, GDNF family receptor alpha 4a antikoerper, glial cell line derived neurotrophic factor family receptor alpha 4 antikoerper, GFRA4 antikoerper, gfra4a antikoerper, Gfra4 antikoerper

Hintergrund: Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRα-1 (previously designated GDNFR-α), GFRα-2 (also designated RETL2), GFRα-3 and GFRα-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRα-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.Synonyms: GDNF family receptor alpha-4, GDNF receptor alpha-4, GFR-alpha-4, Persephin receptor

Molekulargewicht: approx. 30 kDa

Gen-ID: 64096

NCBI Accession: NP_071422

UniProt: Q9GZZ7