OXER1 Antikörper

Produktnummer ABIN317873

Produktdetails anti-OXER1 Antikörper

Target: OXER1 (Oxoeicosanoid Receptor 1 (OXER1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OXER1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TG1019 antibody detects endogenous levels of TG1019 protein.(region surrounding Arg251)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu OXER1

Target: OXER1 (Oxoeicosanoid Receptor 1 (OXER1))

Andere Bezeichnung: Oxoeicosanoid Receptor 1 (OXER1 Produkte)

Synonyme: GPCR antikoerper, GPR170 antikoerper, TG1019 antikoerper, oxoeicosanoid receptor 1 antikoerper, OXER1 antikoerper

Hintergrund: TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils. TG1019 is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocyte, lung and spleen. TG1019 interacts with the protein OXE to form TG1019/OXE, a Gα i/o protein-coupled receptor. Signals from TG1019 are transduced via a Gα i/o protein to PLC/calcium, MEK/ERK and PI3K/Akt pathways. Signal transduction from TG1019 following stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways. TG1019 also may play a role in downregulating cAMP production.Synonyms: 5-oxo-ETE G-protein coupled receptor, GPR170, OXER1, R527, TG1019

Molekulargewicht: approx. 46 kDa

Gen-ID: 165140

NCBI Accession: NP_683765

UniProt: Q8TDS5

Pathways: cAMP Metabolic Process