PTGER3 Antikörper

Produktnummer ABIN317859

Produktdetails anti-PTGER3 Antikörper

Target: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTGER3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of EP3 protein.(region surrounding Arg39)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PTGER3

Target: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Andere Bezeichnung: PTGER3 (PTGER3 Produkte)

Synonyme: PTGER3 antikoerper, EP3 antikoerper, EP3-I antikoerper, EP3-II antikoerper, EP3-III antikoerper, EP3-IV antikoerper, EP3e antikoerper, PGE2-R antikoerper, PTGEREP3 antikoerper, Rep3 antikoerper, rEP3a antikoerper, rEP3b antikoerper, Pgerep3 antikoerper, Ptgerep3 antikoerper, prostaglandin E receptor 3 antikoerper, prostaglandin E receptor 3 L homeolog antikoerper, prostaglandin E receptor 3 (subtype EP3) antikoerper, PTGER3 antikoerper, ptger3.L antikoerper, Ptger3 antikoerper

Hintergrund: Prostaglandin E2, a member of the autacoid family of lipid mediators, is a major renal cyclooxygenase product of arachidonic acid metabolism. Prostaglandin E2 binds to four G protein-coupled E-prostanoid receptors, designated EP1, EP2, EP3 and EP4. The expression and function of the prostaglandin E2 receptors have been highly characterized in kidney. EP1, which is predominantly expressed in the collecting duct, couples to Gq proteins to inhibit sodium absorption and increase in intracellular calcium, which act as second messengers. EP2 is coupled to Gs proteins, which stimulate adenylyl cyclase. EP2 has the lowest expression in kidney, but EP2 knockout mice exhibit saltsensitive hypertension, which suggests a role for EP2 in salt excretion. EP3, which is expressed in renal vessels, thick ascending limb and collecting duct, has at least six alternative splice variants that couple to Gi proteins to inhibit cAMP, which subsequently inhibit sodium and water transport. In uterus, EP3 induces the contraction of uterine smooth muscles. EP4 is expressed in glomerulus and collecting duct.Synonyms: EP3, EP3-II, EP3-III, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, PGE2-R, Prostaglandin E receptor 3, Prostaglandin E2 receptor EP3 subtype, Prostanoid EP3 receptor

Molekulargewicht: approx. 40 kDa

Gen-ID: 5733

NCBI Accession: NP_001119516

UniProt: P43115