MC4R Antikörper

Produktnummer ABIN317754

Produktdetails anti-MC4R Antikörper

Target: MC4R (Melanocortin 4 Receptor (MC4R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC4R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: MC4-R antibody detects endogenous levels of MC4-R protein.(region surrounding Glu315)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MC4R

Target: MC4R (Melanocortin 4 Receptor (MC4R))

Andere Bezeichnung: MC4-R (MC4R Produkte)

Synonyme: zMC4 antikoerper, si:dkey-151m6.62 antikoerper, mc4r antikoerper, MC4R antikoerper, LOC100218148 antikoerper, Mc4-r antikoerper, melanocortin 4 receptor antikoerper, mc4r antikoerper, MC4R antikoerper, Mc4r antikoerper

Hintergrund: MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. With the exception of MC2R, all MCRs are activated by both adrenocorticotropin (ACTH) and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC4R receptor is expressed primarily in the brain, and unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. Genetic studies of mice and humans have established a critical role of MC4 Receptor in appetite regulation. Heterozygous mutations in MC4 Receptor account for 1-6 % of severe cases of human obesity.Synonyms: MC4R, Melanocortin receptor 4

Molekulargewicht: approx. 37 kDa

Gen-ID: 4160

NCBI Accession: NP_005903

UniProt: P32245

Pathways: Hormone Transport, cAMP Metabolic Process, Feeding Behaviour