SLA Antikörper

Produktnummer ABIN306901

Produktdetails anti-SLA Antikörper

Target: SLA (Src-Like-Adaptor (SLA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts with EPHA2, VAV1, LCP2 and PDGFRB. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the human SLAP1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu SLA

Target: SLA (Src-Like-Adaptor (SLA))

Andere Bezeichnung: SLAP1 (Src-like Adaptor Protein-1) (SLA Produkte)

Synonyme: SLA1 antikoerper, SLAP antikoerper, src-like-adapter antikoerper, SLA antikoerper, Slap1 antikoerper, Slap antikoerper, Slap-1 antikoerper, Src like adaptor antikoerper, Src-like-adaptor antikoerper, src-like adaptor antikoerper, SLA antikoerper, Sla antikoerper

UniProt: Q13239