CACNA1C Antikörper

Produktnummer ABIN306889

Produktdetails anti-CACNA1C Antikörper

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNA1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3, Voltage-dependent calcium channel gamma-3 subunit,Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits 1, 2/ , in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the 1 subunits contain the ion channel pore while the auxiliary 2/ and subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the 1, 2/ , core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed 1. Upon co-expression with the 1.1, 2/ 1, 1a subunits of the skeletal muscle VDCC, subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel2. Together, these results suggest that subunits modulate skeletal muscle VDCCs by stabilising their conformation. The 3 subunit is specifically localized in the brain, with the 2 and 4 subunits. It shares >60 % sequence homology with the 2 and 4 subunits and ~25 % sequence homology with the 1 and 5 subunits.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the rat calcium channel gamma3 subunit conjugated to KLH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This antibody can be used for Western blotting at 5-10 μg/mL. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu CACNA1C

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Andere Bezeichnung: Calcium Channel (CACNA1C Produkte)

Synonyme: CACH2 antikoerper, CACN2 antikoerper, CACNL1A1 antikoerper, CCHL1A1 antikoerper, CaV1.2 antikoerper, LQT8 antikoerper, TS antikoerper, Cav1.2 antikoerper, Cchl1a1 antikoerper, MBC antikoerper, MELC-CC antikoerper, RATIVS302 antikoerper, isl antikoerper, C-LTCC antikoerper, CHCACHA1C antikoerper, ICA antikoerper, cav1.2 antikoerper, ca(v)1.2 antikoerper, CAV1.2 antikoerper, BCR antikoerper, rbc antikoerper, calcium voltage-gated channel subunit alpha1 C antikoerper, calcium channel, voltage-dependent, L type, alpha 1C subunit antikoerper, voltage-dependent L-type calcium channel subunit alpha-1C antikoerper, calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog antikoerper, Red blood cell count antikoerper, RNA, 7SL, cytoplasmic 263, pseudogene antikoerper, CACNA1C antikoerper, Cacna1c antikoerper, cacna1c antikoerper, LOC100442085 antikoerper, cacna1c.S antikoerper, RBC antikoerper, RN7SL263P antikoerper

UniProt: O60359

Pathways: Hormone Transport, Carbohydrate Homeostasis