RIT1 Antikörper

Produktnummer ABIN306805

Produktdetails anti-RIT1 Antikörper

Target: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: His-tagged recombinant human Rit protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody detects recombinant Rit protein expressed in HEK-293 cells by Western blot analysis. Shows minimal cross-reactivity with Rin protein and other Ras proteins. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu RIT1

Target: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Andere Bezeichnung: Rit (RIT1 Produkte)

Synonyme: NS8 antikoerper, RIBB antikoerper, RIT antikoerper, ROC1 antikoerper, RIT1 antikoerper, rit1 antikoerper, MGC79097 antikoerper, RGD1559874 antikoerper, si:ch211-93a2.3 antikoerper, Rit antikoerper, Ras like without CAAX 1 antikoerper, Ras-like without CAAX 1 L homeolog antikoerper, Ras-like without CAAX 1 antikoerper, RIT1 antikoerper, rit1.L antikoerper, Rit1 antikoerper, rit1 antikoerper

UniProt: Q92963

Pathways: Neurotrophin Signalübertragung