HSD17B2 Antikörper (C-Term)
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- Target Alle HSD17B2 Antikörper anzeigen
- HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))
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Bindungsspezifität
- AA 373-387, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HSD17B2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Verwendungszweck
- Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 2(HSD17B2) detection. Tested with WB, IHC-P, IHC-F in Human.
- Sequenz
- MPRALRMPNY KKKAT
- Kreuzreaktivität (Details)
- No cross reactivity with other proteins.
- Produktmerkmale
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Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 2(HSD17B2) detection. Tested with WB, IHC-P, IHC-F in Human.
Gene Name: hydroxysteroid(17-beta) dehydrogenase 2
Protein Name: Estradiol 17-beta-dehydrogenase 2 - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B2(373-387aa MPRALRMPNYKKKAT).
- Isotyp
- IgG
- Top Product
- Discover our top product HSD17B2 Primärantikörper
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- Applikationshinweise
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Konservierungsmittel
- Thimerosal (Merthiolate), Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Haltbarkeit
- 12 months
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- Target
- HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))
- Andere Bezeichnung
- HSD17B2 (HSD17B2 Produkte)
- Synonyme
- EDH17B2 antikoerper, HSD17 antikoerper, SDR9C2 antikoerper, AI194836 antikoerper, AI194967 antikoerper, AI255511 antikoerper, hydroxysteroid 17-beta dehydrogenase 2 antikoerper, hydroxysteroid (17-beta) dehydrogenase 2 antikoerper, HSD17B2 antikoerper, Hsd17b2 antikoerper, hsd17b2 antikoerper
- Hintergrund
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HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42(43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.
Synonyms: 17 beta HSD 2 antibody|17-beta-HSD 2 antibody|17-beta-hydroxysteroid dehydrogenase type 2 antibody|20 alpha HSD antibody|20 alpha hydroxysteroid dehydrogenase antibody|20 alpha-hydroxysteroid dehydrogenase antibody|20-alpha-HSD antibody|DHB2_HUMAN antibody|E2DH antibody|EDH17B2 antibody|Estradiol 17-beta-dehydrogenase 2 antibody|HSD17 antibody|Hsd17b2 antibody|Hydroxysteroid(17 beta) dehydrogenase 2 antibody|Microsomal 17 beta hydroxysteroid dehydrogenase antibody|Microsomal 17-beta-hydroxysteroid dehydrogenase antibody|SDR9C2 antibody|Testosterone 17 beta dehydrogenase antibody|Testosterone 17-beta-dehydrogenase antibody - UniProt
- P37059
- Pathways
- Steroid Hormone Biosynthesis
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