IGF2R Antikörper (C-Term)

Produktnummer ABIN3044000

Produktdetails anti-IGF2R Antikörper

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Bindungsspezifität: AA 2475-2491, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit IgG polyclonal antibody for Cation-independent mannose-6-phosphate receptor(IGF2R) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Sequenz: TKLVSFHDDS DEDLLHI

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Cation-independent mannose-6-phosphate receptor(IGF2R) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: insulin-like growth factor 2 receptor
Protein Name: Cation-independent mannose-6-phosphate receptor

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent)(2475-2491aa TKLVSFHDDSDEDLLHI), different from the related rat and mouse sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-IGF2R Antikörper (ABIN3044000)

Liang, Hao, Zhang, Wu, Wang: "Insulin-like growth factors in endometrioid adenocarcinoma: correlation with clinico-pathological features and estrogen receptor expression." in: BMC cancer, Vol. 12, pp. 262, (2013) (PubMed).

Details zu IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Andere Bezeichnung: IGF2R (IGF2R Produkte)

Synonyme: CD222 antikoerper, CIMPR antikoerper, M6P-R antikoerper, MPR1 antikoerper, MPRI antikoerper, AI661837 antikoerper, CI-MPR antikoerper, M6P/IGF2R antikoerper, Mpr300 antikoerper, mpri antikoerper, cd222 antikoerper, cimpr antikoerper, m6p-r antikoerper, insulin like growth factor 2 receptor antikoerper, insulin-like growth factor 2 receptor antikoerper, IGF2R antikoerper, Igf2r antikoerper, igf2r antikoerper

Hintergrund: Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

Synonyms: 300 kDa mannose 6 phosphate receptor antibody|300 kDa mannose 6-phosphate receptor antibody|Cation independent mannose 6 phosphate receptor antibody|Cation-independent mannose-6-phosphate receptor antibody|CD222 antibody|CD222 antigen antibody|CI Man 6 P receptor antibody|CI Man-6-P receptor antibody|CI MPR antibody|CI-MPR antibody|CIMPR antibody|IGF 2 receptor antibody|IGF 2R antibody|IGF II receptor antibody|IGF-II receptor antibody|IGF2 receptor antibody|IGF2R antibody|Insulin like growth factor 2 receptor antibody|Insulin like growth factor II receptor antibody|Insulin-like growth factor 2 receptor antibody|Insulin-like growth factor II receptor antibody|M6P R antibody|M6P/IGF2 receptor antibody|M6P/IGF2R antibody|M6PR antibody|MPR 300 antibody|MPR300 antibody|MPRI antibody|MPRI_HUMAN antibody

UniProt: P11717