GJB2 Antikörper (N-Term)

Produktnummer ABIN3043684

Produktdetails anti-GJB2 Antikörper

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Bindungsspezifität: AA 1-16, N-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Gap junction beta-2 protein(GJB2) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: MDWGTLQTIL GGVNKH

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Gap junction beta-2 protein(GJB2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: gap junction protein, beta 2, 26 kDa
Protein Name: Gap junction beta-2 protein

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GJB2(1-16aa, MDWGTLQTILGGVNKH), different from the related mouse and rat sequences by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu GJB2

Target: GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))

Andere Bezeichnung: GJB2 (GJB2 Produkte)

Synonyme: ppk antikoerper, cx26 antikoerper, dfna3 antikoerper, dfnb1 antikoerper, nsrd1 antikoerper, dfna3a antikoerper, dfnb1a antikoerper, MGC53062 antikoerper, connexin-26 antikoerper, GJB2 antikoerper, AI325222 antikoerper, Cnx26 antikoerper, Cx26 antikoerper, Gjb-2 antikoerper, CXN-26 antikoerper, CX26 antikoerper, DFNA3 antikoerper, DFNA3A antikoerper, DFNB1 antikoerper, DFNB1A antikoerper, HID antikoerper, KID antikoerper, NSRD1 antikoerper, PPK antikoerper, gap junction protein beta 2 L homeolog antikoerper, gap junction protein beta 2 antikoerper, gap junction protein, beta 2 antikoerper, gjb2.L antikoerper, GJB2 antikoerper, Gjb2 antikoerper

Hintergrund: Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.

Synonyms: connexin 26 antibody|Connexin-26 antibody|cx26 antibody|CXB2_HUMAN antibody|DFNA3 antibody|DFNB1 antibody|Gap junction beta-2 protein antibody|GJB2 antibody|HID antibody|KID antibody|NSRD1 antibody|PPK antibody

UniProt: P29033

Pathways: Sensory Perception of Sound, Cell-Cell Junction Organization