Somatostatin Receptor 2 (SSTR2) (AA 184-198), (Middle Region) Antikörper

Details zu Produkt Nr. ABIN3043097
Antigen
  • Smstr2
  • SSTR-2
  • Smstr-2
  • sst2
  • SS2R
  • SSTR2
  • MGC80373
  • somatostatin receptor 2
  • somatostatin receptor 2 L homeolog
  • SSTR2
  • Sstr2
  • sstr2.L
Epitop
AA 184-198, Middle Region
12
4
4
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Ratte (Rattus)
87
56
54
11
10
8
8
6
6
6
5
5
4
3
1
1
Wirt
Kaninchen
86
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
3
3
3
3
3
3
1
1
Applikation
Western Blotting (WB)
45
24
17
15
9
6
2
1
1
1
1
1
Optionen
Verwendungszweck Rabbit IgG polyclonal antibody for Somatostatin receptor type 2(SSTR2) detection. Tested with WB in Human,Mouse,Rat.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human Somatostatin Receptor 2(184-198aa RSNQWGRSSCTINWP), identical to the related rat and mouse sequences.
Sequenz RSNQWGRSSC TINWP
Isotyp IgG
Kreuzreaktivität (Details) Predicted Cross Reactivity: human, mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
Produktmerkmale Rabbit IgG polyclonal antibody for Somatostatin receptor type 2(SSTR2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: somatostatin receptor 2
Protein Name: Somatostatin receptor type 2(SS-2-R/SS2-R/SS2R)
Reinigung Immunogen affinity purified.
Antigen
Andere Bezeichnung SSTR2 (SSTR2 Antibody Abstract)
Hintergrund SSTR2(Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.

Synonyms: Somatostatin receptor type 2 antibody|SRIF-1 antibody|SRIF1 antibody|SS-2-R antibody|SS2-R antibody|SS2R antibody|SSR2_HUMAN antibody|SST2 antibody|SSTR2 antibody
UniProt P30874
Applikations-hinweise WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Kommentare

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Konzentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Konservierungs-mittel Thimerosal (Merthiolate), Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Somatostatin Receptor 2 (SSTR2) (AA 184-198), (Middle Region) antibody (ABIN3043097) Anti- SSTR2 antibody, Western blotting All lanes: Anti SSTR2 at 0.5ug/ml WB: Rat Lun...
Produkt verwendet in: Li, Wang, Wang, Zhang, Wu, Yang, Ji, Li, Wang: "Occludin downregulation in high glucose is regulated by SSTR2 via the VEGF/NRP1/Akt signaling pathway in RF/6A cells." in: Experimental and therapeutic medicine, Vol. 14, Issue 2, pp. 1732-1738, 2017 (PubMed).

Guo, Shi, Zhou, Chen: "Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 14, Issue 7, pp. 4071-5, 2013 (PubMed).

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