SLC6A1 Antikörper (C-Term)

Produktnummer ABIN3032687

Produktdetails anti-SLC6A1 Antikörper

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC6A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human GABA Transporter 1 (WFYGVNRFYDNIQEM) was used as the immunogen for this GAT-1 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the GAT-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the GAT-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu SLC6A1

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Andere Bezeichnung: GAT-1 (GAT1 Produkte)

Synonyme: GABATHG antikoerper, GABATR antikoerper, GAT1 antikoerper, A730043E01 antikoerper, GAT-1 antikoerper, Gabt antikoerper, Gabt1 antikoerper, Gat1 antikoerper, XT-1 antikoerper, Xtrp1 antikoerper, si:ch211-280e18.1 antikoerper, si:dkey-164m14.1 antikoerper, slc6a1 antikoerper, solute carrier family 6 member 1 antikoerper, solute carrier family 6 (neurotransmitter transporter, GABA), member 1 antikoerper, solute carrier family 6 (neurotransmitter transporter, GABA), member 1, like antikoerper, GABA neurotransmitter transporter 1 antikoerper, SLC6A1 antikoerper, Slc6a1 antikoerper, slc6a1l antikoerper, slc6a1 antikoerper

Hintergrund: SLC6A1 (Solute Carrier family 6(Neurotransmitter transporter, Gaba), Member 1), also called GABATR, GABATHG and GAT-1, encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. Zomot et al.(2007) showed that introduction of a negatively charged amino acid at or near one of the two putative sodium binding sites of GAT-1 from rat brain renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the GAT-1 insertion promoter (two copies of the sequence) had significantly greater promoter activity than the noninsertion (one copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that overall expression decreased with age.

UniProt: P30531