SHBG Antikörper (AA 30-210)

Produktnummer ABIN3032554

Produktdetails anti-SHBG Antikörper

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Bindungsspezifität: AA 30-210

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHBG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 30-210) was used as the immunogen for this SHBG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the SHBG antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SHBG antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Andere Bezeichnung: SHBG (SHBG Produkte)

Synonyme: ABP antikoerper, SBP antikoerper, TEBG antikoerper, Abpa antikoerper, shbgl antikoerper, wu:fb66h07 antikoerper, wu:fd55b08 antikoerper, zgc:123063 antikoerper, shbg antikoerper, sex hormone binding globulin antikoerper, sex hormone-binding globulin antikoerper, sex hormone binding globulin L homeolog antikoerper, SHBG antikoerper, Shbg antikoerper, shbg antikoerper, shbg.L antikoerper

Hintergrund: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce it include the brain, uterus, testes, and placenta. It has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Gen-ID: 6462

Pathways: Hormone Transport