OLR1 Antikörper (Middle Region)

Produktnummer ABIN3032107

Produktdetails anti-OLR1 Antikörper

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human LOX-1/OLR1 (NEKSKEQMELHHQN) was used as the immunogen for this LOX-1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the LOX-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the LOX-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu OLR1

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Andere Bezeichnung: LOX-1 (OLR1 Produkte)

Synonyme: OLR1 antikoerper, LOX1 antikoerper, Olr1 antikoerper, CLEC8A antikoerper, LOXIN antikoerper, SCARE1 antikoerper, SLOX1 antikoerper, LOX-1 antikoerper, SR-EI antikoerper, Scare1 antikoerper, Oldlr1 antikoerper, Oldr1 antikoerper, PLOX-1 antikoerper, oxidized low density lipoprotein receptor 1 antikoerper, oxidized low density lipoprotein (lectin-like) receptor 1 antikoerper, OLR1 antikoerper, Olr1 antikoerper

Hintergrund: OLR1 (oxidized low density lipoprotein(lectin-like) receptor 1), also called CLEC8A and LOX-1 (Lectin type oxidized LDL receptor 1), is a receptor which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL). The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on OLR1/LOX-1 expression, but incubation with OxLDL resulted in a dose-dependent increase in mRNA and protein expression. LOX-1 is expressed in macrophages, but not in vascular smooth muscle cells, suggesting a role for the receptor in the pathophysiology of atherosclerotic cardiovascular disease.

UniProt: P78380