OLR1 Antikörper (N-Term)

Produktnummer ABIN3032106

Produktdetails anti-OLR1 Antikörper

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human LOX-1/OLR1 (MTFDDLKIQTVKDQPD) was used as the immunogen for this LOX-1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the LOX-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the LOX-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu OLR1

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Andere Bezeichnung: LOX-1 (OLR1 Produkte)

Synonyme: OLR1 antikoerper, LOX1 antikoerper, Olr1 antikoerper, CLEC8A antikoerper, LOXIN antikoerper, SCARE1 antikoerper, SLOX1 antikoerper, LOX-1 antikoerper, SR-EI antikoerper, Scare1 antikoerper, Oldlr1 antikoerper, Oldr1 antikoerper, PLOX-1 antikoerper, oxidized low density lipoprotein receptor 1 antikoerper, oxidized low density lipoprotein (lectin-like) receptor 1 antikoerper, OLR1 antikoerper, Olr1 antikoerper

Hintergrund: OLR1 (oxidized low density lipoprotein(lectin-like) receptor 1) also called CLEC8A and LOX-1 (Lectin type oxidized LDL receptor 1), is a receptor protein which belongs to theC-type lectin superfamily. Thegene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein(OxLDL). Incubation of the cells with LDL had no effect on LOX-1 expression, but incubation with OxLDL resulted in a dose-dependent increase in mRNA and protein expression, however, very high concentrations of OxLDL caused a decrease in protein expression, perhaps indicating toxic effects on endothelial cells. LOX1 is expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for the protein in the pathophysiology of atherosclerotic cardiovascular disease. Expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX-1 within the posterior segments of normal eyes. It plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.

UniProt: P78380