Dieser Monoamine Oxidase B Antikörper ist unkonjugiert
Applikation
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
Antigen affinity
Immunogen
An amino acid sequence from the N-terminus of mouse Monoamine Oxidase B (RTYTIRNKNVKYVDL) was used as the immunogen for this Monoamine Oxidase B antibody (100% rat homology).
MAOB
Reaktivität: Human, Maus
WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
The stated application concentrations are suggested starting amounts. Titration of the Monoamine Oxidase B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Lagerung
-20 °C
Informationen zur Lagerung
After reconstitution, the Monoamine Oxidase B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Monoamine oxidase B is a protein that in humans is encoded by the MAOB gene. It is a member of the flavin monoamine oxidase family. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAOB is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAOB inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.