FSTL3 Antikörper (AA 145-159)

Produktnummer ABIN3030980

Produktdetails anti-FSTL3 Antikörper

Target: FSTL3 (Follistatin-Like 3 (Secreted Glycoprotein) (FSTL3))

Bindungsspezifität: AA 145-159

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FSTL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids 145-159 (ECELRAARCRGHPDL-human) were used as the immunogen for this FSTL3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the FSTL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the FSTL3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu FSTL3

Target: FSTL3 (Follistatin-Like 3 (Secreted Glycoprotein) (FSTL3))

Andere Bezeichnung: FSTL3 (FSTL3 Produkte)

Synonyme: E030038F23Rik antikoerper, Flrg antikoerper, FLRG antikoerper, FSRP antikoerper, follistatin-like 3 antikoerper, follistatin like 3 antikoerper, Fstl3 antikoerper, FSTL3 antikoerper

Hintergrund: Follistatin-Like 3, also known as FLRG, is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. The FSTL3 gene extends over 7 kbp and contains 5 exons. By Southern blot analysis of somatic cell hybrids and FISH, Hayette et al.(1998) localized the gene to chromosome 19p13. Using recombinant mouse protein, Tsuchida et al.(2000) found that FSTL3 bound both activin and BMP2 and had a higher affinity for activin. Overexpression of the protein inhibited BMP2-induced cell signaling in a reporter assay. In addition to the translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, Hayette et al.(1998) also observed rearrangement of the gene in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.

UniProt: O95633