EIF6 Antikörper (Middle Region)

Produktnummer ABIN3030895

Produktdetails anti-EIF6 Antikörper

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human Eukaryotic Translation Initiation Factor 6 (QHIRNSLPDTVQIRR) was used as the immunogen for this EIF6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the EIF6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the EIF6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu EIF6

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Andere Bezeichnung: EIF6 (EIF6 Produkte)

Synonyme: CAB antikoerper, EIF3A antikoerper, ITGB4BP antikoerper, b(2)gcn antikoerper, eIF-6 antikoerper, p27(BBP) antikoerper, p27BBP antikoerper, 1110004P11 antikoerper, AA408895 antikoerper, Itgb4bp antikoerper, imc-415 antikoerper, MGC56562 antikoerper, itgb4bp4 antikoerper, zgc:56562 antikoerper, wu:fc28a04 antikoerper, wu:ft88f05 antikoerper, itgb4bp antikoerper, eukaryotic translation initiation factor 6 antikoerper, Eukaryotic translation initiation factor 6 antikoerper, eukaryotic translation initiation factor 6 S homeolog antikoerper, translation initiation factor eIF6 antikoerper, EIF6 antikoerper, Eif6 antikoerper, eif6 antikoerper, eif-6 antikoerper, eif6.S antikoerper, tif6 antikoerper

Hintergrund: EIF6 (Eukaryotic Translation Initiation Factor 6), also called ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al.(1998) mapped the gene to 20q11.2. Ceci et al.(2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, it is bound to free 60S but not to 80S subunits. Furthermore, the protein interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al.(2008) demonstrated that the protein is required for efficient initiation of translation in vivo. Null mouse embryos were lethal at preimplantation. Heterozygous mice had 50 % reduction of EIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.

UniProt: P56537

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly