ABCC4 Antikörper (AA 1-370)

Produktnummer ABIN3030055

Produktdetails anti-ABCC4 Antikörper

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Bindungsspezifität: AA 1-370

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 1-370) was used as the immunogen for this MRP4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Titration of the MRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: The lyophilized MRP4 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu ABCC4

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Andere Bezeichnung: MRP4 (ABCC4 Produkte)

Synonyme: EST170205 antikoerper, MOAT-B antikoerper, MOATB antikoerper, MRP4 antikoerper, D630049P08Rik antikoerper, Mrp4 antikoerper, ATP binding cassette subfamily C member 4 antikoerper, multidrug resistance-associated protein 4 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 antikoerper, ABCC4 antikoerper, LOC515333 antikoerper, LOC616707 antikoerper, LOC695407 antikoerper, abcc4 antikoerper, Abcc4 antikoerper

Hintergrund: ABCC4 (ATP-binding cassette, subfamily c, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Gen-ID: 10257