Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
Antigen affinity
Immunogen
An amino acid sequence from the N-terminus of human Amyloid-precursor-like protein 1 (ELQIARVEQATQAIPMERWC) was used as the immunogen for this APLP1 antibody.
The stated application concentrations are suggested starting amounts. Titration of the APLP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Lagerung
-20 °C
Informationen zur Lagerung
After reconstitution, the APLP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Target
APLP1
(Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))
aplp antikoerper, MGC115336 antikoerper, APLP antikoerper, Aplp1_retired antikoerper, RGD1561211 antikoerper, amyloid beta precursor like protein 1 antikoerper, amyloid beta precursor like protein 1 L homeolog antikoerper, amyloid beta (A4) precursor-like protein 1 antikoerper, APLP1 antikoerper, aplp1.L antikoerper, aplp1 antikoerper, Aplp1 antikoerper
Hintergrund
Amyloid-precursor-like protein 1 is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimers disease. APLP1 is predominantly expressed in brain, particularly in the cerebral cortex postsynaptic density. The human gene has been mapped to chromosomal region 19q13.1. The gene is 11.8 kb long and contains 17 exons. APLP1 has been considered a candidate gene for CNF. All exon regions of the gene were amplified by the polymerase chain reaction and sequenced from DNA of CNF patients. No differences were observed between CNF patients and controls, suggesting that mutations in APLP1 are not involved in the etiology of CNF.