GPR37 Antikörper (Extracellular Domain, N-Term)

Produktnummer ABIN302333

Produktdetails anti-GPR37 Antikörper

Target: GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))

Bindungsspezifität: Extracellular Domain, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR37 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects PAEL Receptor (GPR37).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: GPR37 antibody was raised against synthetic peptide from N-terminal extracellular domain of human GPR37.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections (3 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Details zu GPR37

Target: GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))

Abstract: GPR37 Produkte

Synonyme: ACCA antikoerper, EDNRBL antikoerper, PAELR antikoerper, hET(B)R-LP antikoerper, AI848630 antikoerper, Pael-R antikoerper, Ednrbl antikoerper, G protein-coupled receptor 3 antikoerper, G protein-coupled receptor 37 antikoerper, GPR3 antikoerper, GPR37 antikoerper, Gpr37 antikoerper

Hintergrund: GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.Synonyms: ETBR-LP-1, Endothelin B receptor-like protein 1, G-protein coupled receptor 37, PAELR, Parkin-associated endothelin receptor-like receptor

Gen-ID: 2861

NCBI Accession: NP_005293

UniProt: O15354