MAPK8/9/10 Antikörper (pThr221, pTyr223)

Produktnummer ABIN3020001

Produktdetails anti-MAPK8/9/10 Antikörper

Target: MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))

Bindungsspezifität: pThr221, pTyr223

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK8/9/10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Phosphorylated Antibodies

Immunogen: A phospho specific peptide corresponding to residues surrounding T183 of human JNK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-MAPK8/9/10 Antikörper (ABIN3020001)

Kumar, Wang, Liu, Ding, Dong, Zheng, Ye, Liu: "Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms." in: Hypertension (Dallas, Tex. : 1979), Vol. 72, Issue 2, pp. 331-342, (2018) (PubMed).

Wang, Wang, Liu, Wang, Xu, Liu, Zhu, Chen, Situ, Lin: "Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 340-352, (2018) (PubMed).

Details zu MAPK8/9/10

Target: MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))

Andere Bezeichnung: MAPK8/MAPK9/MAPK10 (MAPK8/9/10 Produkte)

Hintergrund: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016],JNK1/JNK2/JNK3,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,MAPK8/MAPK9/MAPK10

Molekulargewicht: 35 kDa/44 kDa/48 kDa/27 kDa/52 kDa

Gen-ID: 5599, 5601, 5602

UniProt: P45983, P45984, P53779