L3MBTL1 Antikörper (Center)

Produktnummer ABIN2855703

Produktdetails anti-L3MBTL1 Antikörper

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Bindungsspezifität: Center

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser L3MBTL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Kreuzreaktivität: Maus

Kreuzreaktivität (Details): mouse (88 %)

Produktmerkmale: Rabbit polyclonal antibody to L3MBTL (l(3)mbt-like (Drosophila))
L3MBTL antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human L3MBTL. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: HeLaS3 , human L3MBTL-transfected 293T

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-L3MBTL1 Antikörper (ABIN2855703)

Lu, Periz, Lu, Tang, Liu, Zhang, Shah, Thombre, Aljumaah, Li, Mojsilovic-Petrovic, Ji, Johnson, Kalb, Wang: "L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control." in: Nature neuroscience, Vol. 22, Issue 6, pp. 875-886, (2019) (PubMed).

Details zu L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Andere Bezeichnung: L3MBTL (L3MBTL1 Produkte)

Synonyme: C630004G01 antikoerper, L3mbtl antikoerper, mKIAA0681 antikoerper, H-L(3)MBT antikoerper, L3MBTL antikoerper, ZC2HC3 antikoerper, dJ138B7.3 antikoerper, RGD1307316 antikoerper, l(3)mbt-like (Drosophila) antikoerper, L3MBTL1, histone methyl-lysine binding protein antikoerper, l(3)mbt-like 1 (Drosophila) antikoerper, L3mbtl1 antikoerper, L3MBTL1 antikoerper

Hintergrund: This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Cellular Localization: Nucleus

Molekulargewicht: 84 kDa

Gen-ID: 26013

Pathways: Chromatin Binding