HSD3B2 Antikörper

Produktnummer ABIN2855488

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0.05. Paired Wilcoxon's test was used. - figure provided by CiteAb. Source: PMID31992765">

Produktdetails anti-HSD3B2 Antikörper

Target: HSD3B2 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD3B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
HSD3B2 antibody [N3C3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human HSD3B2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.24 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-HSD3B2 Antikörper (ABIN2855488)

Qi, Liu, Zhang, Guo: "Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells." in: Scientific reports, Vol. 10, Issue 1, pp. 1281, (2020) (PubMed).

Details zu HSD3B2

Target: HSD3B2 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2))

Andere Bezeichnung: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2 Produkte)

Synonyme: HSD3B antikoerper, HSDB antikoerper, SDR11E2 antikoerper, Hsd3b1 antikoerper, 3b-HSD antikoerper, HSD3B1 antikoerper, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 antikoerper, HSD3B2 antikoerper, Hsd3b2 antikoerper

Hintergrund: The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene.

Cellular Localization: Endoplasmic reticulum membrane , Mitochondrion membrane

Molekulargewicht: 42 kDa

Gen-ID: 3284

UniProt: P26439

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis