Aconitase 1 Antikörper

Produktnummer ABIN2854415

Produktdetails anti-Aconitase 1 Antikörper

Target: Aconitase 1 (ACO1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aconitase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Produktmerkmale: Rabbit Polyclonal antibody to Aconitase 1 (aconitase 1, soluble)
Aconitase 1 antibody [N1C1]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A431 , HeLa , HepG2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.78 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Aconitase 1

Target: Aconitase 1 (ACO1)

Andere Bezeichnung: aconitase 1 (ACO1 Produkte)

Synonyme: ACONS antikoerper, IREB1 antikoerper, IREBP antikoerper, IREBP1 antikoerper, IRP1 antikoerper, Acon1 antikoerper, Ratireb antikoerper, ratireb antikoerper, Aco1 antikoerper, AI256519 antikoerper, Aco-1 antikoerper, Irebp antikoerper, Irp1 antikoerper, aconitase 1 antikoerper, aconitase 1, soluble antikoerper, aconitase 1 L homeolog antikoerper, ACO1 antikoerper, Aco1 antikoerper, aco1.L antikoerper

Hintergrund: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Cellular Localization: Cytoplasm

Molekulargewicht: 98 kDa

Gen-ID: 48

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis