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beta 2 Adrenergic Receptor (BAR2) (AA 1-30), (N-Term) Antikörper

Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB10325 unconjugated
Produktnummer ABIN391396
  • Target
    beta 2 Adrenergic Receptor (BAR2)
    Bindungsspezifität
    AA 1-30, N-Term
    Reaktivität
    Human
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    Western Blotting (WB)
    Spezifität
    This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7~37 amino acids from the N-terminal region of human BAR2.
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This beta 2 Adrenergic Receptor (BAR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human beta 2 Adrenergic Receptor (BAR2).
    Klon
    RB10325
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB = 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.42 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Simkins, Crawford, Goudreau, Lookingland, Kaplan: "Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 9, Issue 4, pp. 544-57, (2014) (PubMed).

    Rodrigues, Tran, Fortes, Schmid-Schönbein: "Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats." in: American journal of physiology. Heart and circulatory physiology, Vol. 299, Issue 1, pp. H25-35, (2010) (PubMed).

  • Target
    beta 2 Adrenergic Receptor (BAR2)
    Hintergrund
    This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
    Synonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR
    Molekulargewicht
    46426 DA
    Gen-ID
    154
    NCBI Accession
    NP_000015
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