GCM1 Antikörper (Glial Cells Missing Homolog 1 (Drosophila)) (N-Term)

Details for Product anti-GCM1 Antibody No. ABIN2792608, Anbieter: Anmelden zum Anzeigen
Antigen
  • GCM1
  • GCM
  • GCM-1
  • GCMA
  • hGCMa
  • GCMa
  • Gcm-rs2
  • Gcm1-rs1
  • glide
  • Gcma
  • glial cells missing homolog 1
  • glial cells missing homolog 1 (Drosophila)
  • GCM1
  • Gcm1
Epitop
N-Term
13
6
3
3
2
2
1
1
1
1
Reaktivität
Hund, Human, Maus, Ratte (Rattus)
48
20
19
3
3
2
2
1
1
1
1
1
Wirt
Kaninchen
35
15
Klonalität
Polyklonal
Konjugat
Dieser GCM1 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
35
17
17
13
7
7
1
1
Optionen
Hersteller
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human GCM1
Sequenz MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK
Kreuzreaktivität Hund, Human, Maus, Ratte (Rattus)
Homologie Dog: 78%, Human: 92%, Mouse: 78%, Rat: 78%
Produktmerkmale This is a rabbit polyclonal antibody against GCM1. It was validated on Western Blot and immunohistochemistry.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere GCM1 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung GCM1 / GCMA (GCM1 Antibody Abstract)
Hintergrund GCM1 is a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-132 D88613.1 1-132 133-2763 AB026493.1 1-2631
Alias Symbols: GCMA, hGCMa
Protein Interaction Partner: FBXW2, UBC, SENP1, CAMK1, SUMO1, DUSP23, CREBBP, HDAC5, HDAC4, HDAC3, HDAC1, CUL1, SKP1, UBE2I,
Protein Size: 436
Molekulargewicht 49 kDa
Gen-ID 8521
NCBI Accession NM_003643, NP_003634
UniProt Q9NP62
Applikations-hinweise WB Suggested Anti-GCM1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:7812500
Positive Control: Human Placenta.
Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 436 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) WB Suggested Anti-GCM1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:7812500 Pos...
Immunohistochemistry (IHC) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Human Spleen
Immunohistochemistry (IHC) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Human Lung
Western Blotting (WB) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Human 293T
Immunohistochemistry (IHC) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Human Lung
Immunohistochemistry (IHC) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Human Spleen
Western Blotting (WB) image for anti-Glial Cells Missing Homolog 1 (Drosophila) (GCM1) (N-Term) antibody (ABIN2792608) Host: Rabbit Target Name: GCM1 Sample Tissue: Human 293T Antibody Dilution: 1....
Produkt verwendet in: Bailey, Alahari, Tagliaferro, Post, Caniggia: "Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis." in: Cell death & disease, Vol. 8, Issue 2, pp. e2590, 2017 (PubMed).

Moretto Zita, Soncin, Natale, Pizzo, Parast: "Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 30152-62, 2015 (PubMed).

Sivasubramaniyam, Garcia, Tagliaferro, Melland-Smith, Chauvin, Post, Todros, Caniggia: "Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia." in: Endocrinology, Vol. 154, Issue 3, pp. 1296-309, 2013 (PubMed).

Kumar, Luo, Tudela, Alexander, Mendelson: "The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation." in: Molecular and cellular biology, Vol. 33, Issue 9, pp. 1782-96, 2013 (PubMed).

Drewlo, Czikk, Baczyk, Lye, Kingdom: "Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi." in: Human reproduction (Oxford, England), Vol. 26, Issue 5, pp. 1025-34, 2011 (PubMed).

Baczyk, Drewlo, Proctor, Dunk, Lye, Kingdom: "Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast." in: Cell death and differentiation, Vol. 16, Issue 5, pp. 719-27, 2009 (PubMed).

Allgemeine Veröffentlichungen Yu, Shen, Lin, Chen, Lin, Chang, Chen: "GCMa regulates the syncytin-mediated trophoblastic fusion." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 50062-8, 2002 (PubMed).

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