SMAD6 Antikörper (N-Term)
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- Target Alle SMAD6 Antikörper anzeigen
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Rind (Kuh), Schwein, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SMAD6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- GAPRDASDPL AGAALEPAGG GRSREARSRL LLLEQELKTV TYSLLKRLKE
- Kreuzreaktivität
- Human
- Homologie
- Cow: 85%, Dog: 91%, Human: 100%, Pig: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SMAD6. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6
- Top Product
- Discover our top product SMAD6 Primärantikörper
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- Applikationshinweise
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WB Suggested Anti-SMAD6 Antibody Titration: 0.2-1 µg/mL
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator. - Kommentare
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Antigen size: 496 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Andere Bezeichnung
- SMAD6 (SMAD6 Produkte)
- Synonyme
- madh6 antikoerper, madh7 antikoerper, Xsmad6 antikoerper, hst17432 antikoerper, AOVD2 antikoerper, HsT17432 antikoerper, MADH6 antikoerper, MADH7 antikoerper, Madh6 antikoerper, b2b390Clo antikoerper, Smad6-like antikoerper, smad6 antikoerper, wu:fb22g05 antikoerper, SMAD family member 6 antikoerper, SMAD family member 6a antikoerper, smad6 antikoerper, SMAD6 antikoerper, Smad6 antikoerper, smad6a antikoerper
- Hintergrund
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SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
Alias Symbols: HsT17432, MADH6, MADH7
Protein Interaction Partner: ITCH, SMURF2, BPIFA1, NEDD4L, WWP2, WWP1, USP15, USP11, PIGR, NASP, LYZ, KPNA2, CTBP2, CTBP1, UBC, ACVR1, UBE2O, BAMBI, STAMBP, ACTR1B, TGFBR1, MYD88, SMAD1, BMPR2, BMPR1B, BMPR1A, ACVR2B, ACVR1B, SMURF1, PELI1, CUL2, ELAVL1, SMAD5, RPS6KA5, TSC22D1, MAPK
Protein Size: 496 - Molekulargewicht
- 53 kDa
- Gen-ID
- 4091
- NCBI Accession
- NM_005585, NP_005576
- UniProt
- O43541
- Pathways
- Chromatin Binding
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