HFE2 Antikörper (N-Term)

Produktnummer ABIN2785415

Produktdetails anti-HFE2 Antikörper

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HFE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV AEDVAMAFSA

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HFE2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HFE2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 200 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Andere Bezeichnung: HFE2 (HFE2 Produkte)

Synonyme: HFE2A antikoerper, HJV antikoerper, JH antikoerper, RGMC antikoerper, HFE2 antikoerper, DKFZp468F2322 antikoerper, 2310035L15Rik antikoerper, 5230400G09Rik antikoerper, AI414844 antikoerper, AI789733 antikoerper, DL-M antikoerper, Rgmc antikoerper, hemojuvelin antikoerper, RGMr antikoerper, hjv antikoerper, id:ibd3464 antikoerper, wu:fb38f10 antikoerper, zgc:136698 antikoerper, hemochromatosis type 2 (juvenile) antikoerper, hemochromatosis type 2 antikoerper, HFE2 antikoerper, Hfe2 antikoerper, hfe2 antikoerper

Hintergrund: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alias Symbols: HFE2A, HJV, JH, MGC23953, RGMC
Protein Size: 200

Molekulargewicht: 21 kDa

Gen-ID: 148738

NCBI Accession: NM_202004, NP_973733

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis