PTPRR Antikörper (C-Term)
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- Target Alle PTPRR Antikörper anzeigen
- PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTPRR Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- NYTIRNLVLK QGSHTQHVKH YWYTSWPDHK TPDSAQPLLQ LMLDVEEDRL
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PTPRR. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human PTPRR
- Top Product
- Discover our top product PTPRR Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 412 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))
- Andere Bezeichnung
- PTPRR (PTPRR Produkte)
- Synonyme
- EC-PTP antikoerper, PCPTP1 antikoerper, PTP-SL antikoerper, PTPBR7 antikoerper, PTPRQ antikoerper, Pcptp1 antikoerper, ec-ptp antikoerper, pcptp1 antikoerper, ptp-sl antikoerper, ptpbr7 antikoerper, PTPRR antikoerper, Gmcp1 antikoerper, RPTPRR antikoerper, mPTP213 antikoerper, protein tyrosine phosphatase, receptor type R antikoerper, protein tyrosine phosphatase, receptor type, R antikoerper, protein tyrosine phosphatase, receptor type R L homeolog antikoerper, protein tyrosine phosphatase, receptor type, r antikoerper, receptor-type tyrosine-protein phosphatase R antikoerper, PTPRR antikoerper, Ptprr antikoerper, ptprr.L antikoerper, ptprr antikoerper, LOC100715069 antikoerper
- Hintergrund
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PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.
Alias Symbols: DKFZp781C1038, EC-PTP, FLJ34328, MGC131968, MGC148170, PCPTP1, PTP-SL, PTPBR7, PTPRQ
Protein Interaction Partner: MAPK3, MAPK1, MAPK7, PRKACA,
Protein Size: 412 - Molekulargewicht
- 46 kDa
- Gen-ID
- 5801
- NCBI Accession
- NM_130846, NP_570897
- UniProt
- Q7Z2V8
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