PTPN2 Antikörper (N-Term)

Produktnummer ABIN971501

Produktdetails anti-PTPN2 Antikörper

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Kaninchen, Meerschweinchen, Pferd, Hund, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PTPN2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTPN2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 415 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PTPN2

Target: PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))

Andere Bezeichnung: PTPN2 (PTPN2 Produkte)

Synonyme: PTN2 antikoerper, PTPT antikoerper, TC-PTP antikoerper, TCELLPTP antikoerper, TCPTP antikoerper, AI325124 antikoerper, Ptpt antikoerper, PTP-1B antikoerper, cb806 antikoerper, ptpn2 antikoerper, ptpn2l antikoerper, wu:fc10h07 antikoerper, zgc:55339 antikoerper, zgc:76973 antikoerper, hm:zeh1546 antikoerper, zgc:63623 antikoerper, ptn2 antikoerper, ptpt antikoerper, tc-ptp antikoerper, tcellptp antikoerper, tcptp antikoerper, protein tyrosine phosphatase, non-receptor type 2 antikoerper, protein tyrosine phosphatase, non-receptor type 2 S homeolog antikoerper, protein tyrosine phosphatase, non-receptor type 2, b antikoerper, protein tyrosine phosphatase, non-receptor type 2, a antikoerper, protein tyrosine phosphatase, non-receptor type 2 L homeolog antikoerper, PTPN2 antikoerper, Ptpn2 antikoerper, ptpn2.S antikoerper, ptpn2b antikoerper, ptpn2a antikoerper, ptpn2.L antikoerper

Hintergrund: PTPN2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
Alias Symbols: PTPT, TC-PTP, TCELLPTP, TCPTP, PTN2
Protein Interaction Partner: UBC, BAG3, STAT1, STAT6, KATNB1, HSPD1, TRAF2, SRC, GHR, UCHL5, FKBP4, STAT5B, KPNB1, STAT5A, SHC1, JAK3, ITGA1, PDGFRB, JAK1, INSR, EGFR, CDK5, CDK2, CDK1, STAT3, SFN,
Protein Size: 415

Molekulargewicht: 48 kDa

Gen-ID: 5771

NCBI Accession: NM_002828, NP_002819

UniProt: P17706

Pathways: EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling