ATP2B4 Antikörper (Middle Region)

Produktnummer ABIN2781844

Produktdetails anti-ATP2B4 Antikörper

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP2B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FAGEKFFDID SGRKAPLHSP PSQHYTIVFN TFVLMQLFNE INSRKIHGEK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against ATP2B4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP2B4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1170 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATP2B4

Target: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Andere Bezeichnung: ATP2B4 (ATP2B4 Produkte)

Synonyme: ATP2B2 antikoerper, MXRA1 antikoerper, PMCA4 antikoerper, PMCA4b antikoerper, PMCA4x antikoerper, atp2b2 antikoerper, atp2b3 antikoerper, mxra1 antikoerper, pmca4 antikoerper, pmca4b antikoerper, pmca4x antikoerper, zgc:152801 antikoerper, ATP2B4 antikoerper, ATP2B1 antikoerper, Pmca4 antikoerper, ATPase plasma membrane Ca2+ transporting 4 antikoerper, ATPase, Ca++ transporting, plasma membrane 4 L homeolog antikoerper, ATPase, Ca++ transporting, plasma membrane 4 antikoerper, ATP2B4 antikoerper, atp2b4.L antikoerper, atp2b4 antikoerper, Atp2b4 antikoerper

Hintergrund: ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B4 is the plasma membrane calcium ATPase isoform 4.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: ATP2B2, DKFZp686G08106, DKFZp686M088, MXRA1, PMCA4, PMCA4b, PMCA4x
Protein Interaction Partner: UBC, CDK7, ADRB2, ERBB2IP, RASSF1, DLG2, DLG4, DLG1, DLG3, CASK, SRC, NOS1, PPP3CA, CD22, PDZD11,
Protein Size: 1170

Molekulargewicht: 129 kDa

Gen-ID: 493

NCBI Accession: NM_001001396, NP_001001396

UniProt: B1APW5

Pathways: Ribonucleoside Biosynthetic Process