ABCC8 Antikörper (N-Term)
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- Target Alle ABCC8 Antikörper anzeigen
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Hund, Rind (Kuh), Schwein, Kaninchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ABCC8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- PLAFCGSENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW
- Homologie
- Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ABCC8. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
- Top Product
- Discover our top product ABCC8 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1581 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).
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Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).
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- Target
- ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
- Andere Bezeichnung
- ABCC8 (ABCC8 Produkte)
- Synonyme
- ABC36 antikoerper, HHF1 antikoerper, HI antikoerper, HRINS antikoerper, MRP8 antikoerper, PHHI antikoerper, SUR antikoerper, SUR1 antikoerper, SUR1delta2 antikoerper, TNDM2 antikoerper, D930031B21Rik antikoerper, Sur antikoerper, Sur1 antikoerper, ATP binding cassette subfamily C member 8 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antikoerper, ABCC8 antikoerper, Abcc8 antikoerper
- Hintergrund
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ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
Protein Interaction Partner: ENSA, KCNJ11, CRYBB1, KCNJ8, RAPGEF4,
Protein Size: 1581 - Molekulargewicht
- 177 kDa
- Gen-ID
- 6833
- NCBI Accession
- NM_000352, NP_000343
- UniProt
- Q09428
- Pathways
- Negative Regulation of Hormone Secretion
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