MARCH8 Antikörper (Middle Region)

Produktnummer ABIN2781250

Produktdetails anti-MARCH8 Antikörper

Target: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YVQCKVYVQL WKRLKAYNRV IYVQNCPETS KKNIFEKSPL TEPNFENKHG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MARCH8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MARCH8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 291 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MARCH8

Target: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Andere Bezeichnung: MARCH8 (MARCH8 Produkte)

Synonyme: MARCH-VIII antikoerper, MIR antikoerper, RNF178 antikoerper, c-MIR antikoerper, zgc:171495 antikoerper, 1300017E09Rik antikoerper, Mir antikoerper, Mar-08 antikoerper, MARCH8 antikoerper, membrane associated ring-CH-type finger 8 antikoerper, membrane-associated ring finger (C3HC4) 8 antikoerper, membrane associated ring-CH-type finger 8 L homeolog antikoerper, MARCH8 antikoerper, march8 antikoerper, March8 antikoerper, march8.L antikoerper

Hintergrund: MARCH8 is an E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. It may also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Alias Symbols: MARCH-VIII, MIR, RNF178, c-MIR
Protein Interaction Partner: TNFRSF10A, UBC, UBE2H, UBE2D1, TFRC, UBE2D3, IL1RAP, IL1R1, CD86,
Protein Size: 291

Molekulargewicht: 33 kDa

Gen-ID: 220972

NCBI Accession: NM_145021, NP_659458

UniProt: Q5T0T0