JARID2 Antikörper (Middle Region)

Produktnummer ABIN2780036

Produktdetails anti-JARID2 Antikörper

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Kaninchen, Meerschweinchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JARID2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK

Homologie: Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against Jarid2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse Jarid2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1234 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu JARID2

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Andere Bezeichnung: Jarid2 (JARID2 Produkte)

Synonyme: JMJ antikoerper, Jmj antikoerper, jumonji antikoerper, JARID2 antikoerper, jarid2 antikoerper, jmj antikoerper, si:dkey-211c3.1 antikoerper, Jumonji antikoerper, jarid2-a antikoerper, jarid2-b antikoerper, jarid2.S antikoerper, jarid2b antikoerper, jumonji and AT-rich interaction domain containing 2 antikoerper, jumonji, AT rich interactive domain 2 antikoerper, jumonji, AT rich interactive domain 2a antikoerper, jumonji, AT rich interactive domain 2b antikoerper, jumonji and AT-rich interaction domain containing 2 L homeolog antikoerper, JARID2 antikoerper, Jarid2 antikoerper, jarid2a antikoerper, jarid2 antikoerper, jarid2b antikoerper, jarid2.L antikoerper

Hintergrund: Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
Protein Interaction Partner: Rb1, Suz12, Ewsr1, Ell, Eed, Aebp2, Morc3, Setx, Stk38l, Thrap3, Ice1, Stk38, Bclaf1, Trim35, Rbbp4, Mtf2, Ezh2, Ezh1,
Protein Size: 1234

Molekulargewicht: 137 kDa

Gen-ID: 16468

NCBI Accession: NM_021878, NP_068678

UniProt: Q62315

Pathways: Chromatin Binding