TAF15 Antikörper (N-Term)

Produktnummer ABIN2779282

Produktdetails anti-TAF15 Antikörper

Target: TAF15 (TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAF15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GGRGRGGYDK DGRGPMTGSS GGDRGGFKNF GGHRDYGPRT DADSESDNSD

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TAF15. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAF15

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 592 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TAF15 Antikörper (ABIN2779282)

Perez, Martínez, Cosme-Cruz, Perez-Crespo, Tang: "A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replication." in: Journal of virology, Vol. 87, Issue 5, pp. 2639-47, (2013) (PubMed).

Lee, Kim, Pelletier, Kim: "Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src." in: FEBS letters, Vol. 564, Issue 1-2, pp. 188-98, (2004) (PubMed).

Details zu TAF15

Target: TAF15 (TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15))

Andere Bezeichnung: TAF15 (TAF15 Produkte)

Synonyme: 2610111C21Rik antikoerper, 68kDa antikoerper, TAFII68 antikoerper, Taf2n antikoerper, Npl3 antikoerper, RBP56 antikoerper, TAF2N antikoerper, TATA-box binding protein associated factor 15 antikoerper, Taf15 antikoerper, TAF15 antikoerper

Hintergrund: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF15 encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas.
Alias Symbols: Npl3, RBP56, TAF2N, TAFII68, hTAFII68
Protein Interaction Partner: RPA3, RPA2, RPA1, SUZ12, RNF2, EZH2, BMI1, EED, UBD, PRMT8, MED26, UBC, FUS, TPR, TPM2, DDB1, SCARB2, RNF168, TMED9, SAP30BP, NEDD8, CAND1, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, YWHAZ, SIRT7, HIST2H4A, HIST1H3A, HIST2H2AC, CACNA1A,
Protein Size: 592

Molekulargewicht: 62 kDa

Gen-ID: 8148

NCBI Accession: NM_139215, NP_631961

UniProt: Q92804