DROSHA Antikörper (Middle Region)

Produktnummer ABIN2779039

Produktdetails anti-DROSHA Antikörper

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DROSHA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AAMDALEKYN FPQMAHQKRF IERKYRQELK EMRWEREHQE REPDETEDIK

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RNASEN. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RNASEN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1374 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DROSHA

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Andere Bezeichnung: RNASEN (DROSHA Produkte)

Synonyme: im:7150667 antikoerper, zgc:158612 antikoerper, ETOHI2 antikoerper, HSA242976 antikoerper, RANSE3L antikoerper, RN3 antikoerper, RNASE3L antikoerper, RNASEN antikoerper, 1110013A17Rik antikoerper, AI874853 antikoerper, Etohi2 antikoerper, Rn3 antikoerper, Rnasen antikoerper, RGD1307626 antikoerper, ribonuclease type III, nuclear antikoerper, Ribonuclease 3 antikoerper, ribonuclease 3 antikoerper, drosha ribonuclease III antikoerper, drosha, ribonuclease type III antikoerper, rnasen antikoerper, Thicy_0885 antikoerper, Sinme_0866 antikoerper, Isova_2087 antikoerper, Sphch_0770 antikoerper, DROSHA antikoerper, Drosha antikoerper

Hintergrund: RNASEN is a ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. RNASEN is also involved in pre-rRNA processing. RNASEN cleaves double-strand RNA and does not cleave single-strand RNA. RNASEN is involved in the formation of GW bodies.Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM].
Alias Symbols: DROSHA, ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN
Protein Interaction Partner: DDX5, HNRNPUL2, KLHL12, YLPM1, ZCCHC8, DGCR8, SKIV2L2, U2SURP, KHDRBS1, CARM1, RBM14, PDCD6, THRAP3, PPFIA1, SRPK1, PKP2, MEN1, LGALS3BP, HNRNPAB, WWOX, BMI1, SRPK2, ZNF512B, UBC, CUL3, PSMA1, BCL6, SP1,
Protein Size: 1374

Molekulargewicht: 159 kDa

Gen-ID: 29102

NCBI Accession: NM_013235, NP_037367

UniProt: Q9NRR4

Pathways: Regulatorische RNA Pathways