SYNCRIP Antikörper (Middle Region)

Produktnummer ABIN2778979

Produktdetails anti-SYNCRIP Antikörper

Target: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNCRIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SYNCRIP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SYNCRIP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 623 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SYNCRIP Antikörper (ABIN2778979)

Ting, Wen, Liu, Hsieh-Li, Li, Lin-Chao: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." in: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).

Groen, Fumoto, Blokhuis, Engelen-Lee, Zhou, van den Heuvel, Koppers, van Diggelen, van Heest, Demmers, Kirby, Shaw, Aronica, Spliet, Veldink, van den Berg, Pasterkamp: "ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN." in: Human molecular genetics, Vol. 22, Issue 18, pp. 3690-704, (2013) (PubMed).

Details zu SYNCRIP

Target: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Andere Bezeichnung: SYNCRIP (SYNCRIP Produkte)

Synonyme: GRY-RBP antikoerper, GRYRBP antikoerper, HNRNPQ antikoerper, HNRPQ1 antikoerper, NSAP1 antikoerper, PP68 antikoerper, hnRNP-Q antikoerper, 2610109K23Rik antikoerper, 4632417O19Rik antikoerper, Nsap1 antikoerper, Nsap1l antikoerper, pp68 antikoerper, nsap1 antikoerper, wu:fe02c03 antikoerper, wu:fe47h09 antikoerper, SYNCRIP antikoerper, hnrpq1 antikoerper, gry-rbp antikoerper, rp1-3j17.2 antikoerper, synaptotagmin binding cytoplasmic RNA interacting protein antikoerper, synaptotagmin binding, cytoplasmic RNA interacting protein antikoerper, synaptotagmin binding cytoplasmic RNA interacting protein S homeolog antikoerper, SYNCRIP antikoerper, Syncrip antikoerper, syncrip antikoerper, syncrip.S antikoerper

Hintergrund: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. SYNCRIP may be involved in translationally coupled mRNA turnover. It implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. It interacts in vitro preferentially with poly(A) and poly(U) RNA sequences.
Alias Symbols: GRY-RBP, NSAP1, RP1-3J17.2, dJ3J17.2, pp68, PP68, GRYRBP, HNRPQ1, hnRNP-Q
Protein Interaction Partner: FUS, PRMT8, UBC, SPRTN, SUMO2, SUMO3, STAU1, MDM2, RPA3, RPA2, RPA1, RNF2, EED, rev, GNB2L1, IQGAP1, RPS21, RPL24, RPL23A, PSMD7, RPSA, IARS, PRMT1, HNRNPU, FKBP3, MAP1S, C14orf166, RPS27L, NELFB, PARK2, FBXO6, TARDBP, CSF2, CD81, IGSF8, HMGA2, ICAM1, HMG
Protein Size: 623

Molekulargewicht: 69 kDa

Gen-ID: 10492

NCBI Accession: NM_006372, NP_006363

UniProt: O60506