NCOA2 Antikörper (Middle Region)
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- Target Alle NCOA2 Antikörper anzeigen
- NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Kaninchen, Hund, Rind (Kuh), Meerschweinchen, Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NCOA2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LLPKSIVNGG SWSGEPPRRN SHTFNCRMLV KPLPDSEEEG HDNQEAHQKY
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against NCOA2. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human NCOA2
- Top Product
- Discover our top product NCOA2 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))
- Andere Bezeichnung
- NCOA2 (NCOA2 Produkte)
- Synonyme
- GRIP1 antikoerper, KAT13C antikoerper, NCoA-2 antikoerper, SRC2 antikoerper, TIF2 antikoerper, bHLHe75 antikoerper, 9530095N19 antikoerper, D1Ertd433e antikoerper, GRIP-1 antikoerper, Grip1 antikoerper, SRC-2 antikoerper, TIF-2 antikoerper, tif2 antikoerper, wu:fc41a10 antikoerper, wu:fe26a11 antikoerper, Tif2 antikoerper, NCOA2 antikoerper, XTIF2 antikoerper, bhlhe75 antikoerper, grip1 antikoerper, kat13c antikoerper, src2 antikoerper, ncoa2-A antikoerper, nuclear receptor coactivator 2 antikoerper, nuclear receptor coactivator 2 S homeolog antikoerper, NCOA2 antikoerper, Ncoa2 antikoerper, ncoa2 antikoerper, LOC100089041 antikoerper, ncoa2.S antikoerper
- Hintergrund
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The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
Alias Symbols: SRC2, TIF2, GRIP1, KAT13C, NCoA-2, bHLHe75
Protein Size: 370 - Molekulargewicht
- 40 kDa
- Gen-ID
- 10499
- NCBI Accession
- NM_006540, NP_006531
- UniProt
- Q15596
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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