TRPV4 Antikörper (Middle Region)
-
- Target Alle TRPV4 Antikörper anzeigen
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
-
Bindungsspezifität
- Middle Region
-
Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Kaninchen, Meerschweinchen
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser TRPV4 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- RVDEVNWSHW NQNLGIINED PGKNETYQYY GFSHTVGRLR RDRWSSVVPR
- Homologie
- Cow: 93%, Dog: 86%, Guinea Pig: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against TRPV4. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human TRPV4
- Top Product
- Discover our top product TRPV4 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 811 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
- Andere Bezeichnung
- TRPV4 (TRPV4 Produkte)
- Synonyme
- wu:fp52e02 antikoerper, CMT2C antikoerper, HMSN2C antikoerper, OTRPC4 antikoerper, SMAL antikoerper, SPSMA antikoerper, SSQTL1 antikoerper, TRP12 antikoerper, VRL2 antikoerper, VROAC antikoerper, 0610033B08Rik antikoerper, Trp12 antikoerper, VR-OAC antikoerper, VRL-2 antikoerper, Otrpc4 antikoerper, Vroac antikoerper, transient receptor potential cation channel, subfamily V, member 4 antikoerper, transient receptor potential cation channel subfamily V member 4 antikoerper, trpv4 antikoerper, TRPV4 antikoerper, Trpv4 antikoerper
- Hintergrund
-
TRPV4 is a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation of TRPV4 by exposure to hypotonicity within the physiological range exhibits an outward rectification. TRPV4 also activated by low pH , citrate and phorbol esters and increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: OTRPC4, TRP12, VR-OAC, VRL-2, VRL2, VROAC, CMT2C, SPSMA, HMSN2C, SSQTL1
Protein Interaction Partner: UBC, ARRB2, KRIT1, ITCH, PACSIN3, PACSIN1, TRPV4, PACSIN2, MAP7, SRC, LYN, YES1, LCK, HCK, FYN, CALM1, OS9, PACS1,
Protein Size: 811 - Molekulargewicht
- 91 kDa
- Gen-ID
- 59341
- NCBI Accession
- NM_147204, NP_671737
- Pathways
- Hormone Transport, Cell-Cell Junction Organization
-