DPF3 Antikörper (Middle Region)
-
- Target Alle DPF3 Antikörper anzeigen
- DPF3 (D4, Zinc and Double PHD Fingers, Family 3 (DPF3))
-
Bindungsspezifität
- Middle Region
-
Reaktivität
- Human, Maus, Ratte, Kaninchen, Meerschweinchen, Pferd, Rind (Kuh), Hund
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser DPF3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- KDGFTSESTT LEALLRGEGV EKKVDAREEE SIQEIQRVLE NDENVEEGNE
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against DPF3. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human DPF3
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 357 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia." in: PLoS ONE, Vol. 8, Issue 10, pp. e76155, (2013) (PubMed).
: "Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases." in: Journal of carcinogenesis, Vol. 4, pp. 13, (2005) (PubMed).
: "
-
Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia." in: PLoS ONE, Vol. 8, Issue 10, pp. e76155, (2013) (PubMed).
-
- Target
- DPF3 (D4, Zinc and Double PHD Fingers, Family 3 (DPF3))
- Andere Bezeichnung
- DPF3 (DPF3 Produkte)
- Synonyme
- BAF45C antikoerper, CERD4 antikoerper, 2810403B03Rik antikoerper, 6530402L11Rik antikoerper, C78788 antikoerper, cer-d4 antikoerper, si:ch211-268e23.1 antikoerper, wu:fj43h12 antikoerper, double PHD fingers 3 antikoerper, D4, zinc and double PHD fingers, family 3 antikoerper, DPF3 antikoerper, Dpf3 antikoerper, dpf3 antikoerper
- Hintergrund
-
DPF3 is a muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). DPF3 specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
Alias Symbols: CERD4, FLJ14079
Protein Interaction Partner: SMARCA4, SMARCA2, RELA, NFKB1, SMARCD1, SMARCC1, SMARCB1, ESRRA,
Protein Size: 357 - Molekulargewicht
- 40 kDa
- Gen-ID
- 8110
- NCBI Accession
- NM_012074, NP_036206
- UniProt
- Q92784
-