MARCH2 Antikörper (C-Term)

Produktnummer ABIN2774742

Produktdetails anti-MARCH2 Antikörper

Target: MARCH2 (Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase (MARCH2))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TIALFTIYVL WTLVSFRYHC QLYSEWRKTN QKVRLKIREA DSPEGPQHSP

Homologie: Dog: 92%, Guinea Pig: 86%, Human: 100%, Mouse: 100%, Rabbit: 77%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MARCH2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MARCH2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 246 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MARCH2 Antikörper (ABIN2774742)

Wakisaka, Tsuda, Yamada, Yagihara, Kitamura: "Long-term results of saphenous vein graft for coronary stenosis caused by Kawasaki disease." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 73, Issue 1, pp. 73-7, (2008) (PubMed).

Details zu MARCH2

Target: MARCH2 (Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase (MARCH2))

Andere Bezeichnung: MARCH2 (MARCH2 Produkte)

Synonyme: MARCH-II antikoerper, RNF172 antikoerper, rgd1306395 antikoerper, marh2 antikoerper, RGD1306395 antikoerper, 9530046H09Rik antikoerper, membrane associated ring-CH-type finger 2 antikoerper, membrane associated ring-CH-type finger 2 S homeolog antikoerper, E3 ubiquitin-protein ligase MARCH2 antikoerper, membrane-associated ring finger (C3HC4) 2 antikoerper, MARCH2 antikoerper, march2.S antikoerper, march2 antikoerper, Tsp_09446 antikoerper, marh2 antikoerper, March2 antikoerper

Hintergrund: MARCH2 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH2 may be involved in endosomal trafficking through interaction with STX6.
Alias Symbols: HSPC240, MARCH-II, RNF172
Protein Interaction Partner: LDLRAD1, SYNE4, CCDC155, FATE1, UBE2H, UBE2D1, CDC34, GOPC, STX6, CFTR, ADRB2, ELAVL1, DLG1,
Protein Size: 246

Molekulargewicht: 27 kDa

Gen-ID: 51257

NCBI Accession: NM_016496, NP_057580

UniProt: Q9P0N8