KIR2DL5A Antikörper (C-Term)

Produktnummer ABIN2774436

Produktdetails anti-KIR2DL5A Antikörper

Target: KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR2DL5A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QLDHCVFTQT KITSPSQRPK TPPTDTTMYM ELPNAKPRSL SPAHKHHSQA

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIR2DL5A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KIR2DL5A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 375 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KIR2DL5A

Target: KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))

Andere Bezeichnung: KIR2DL5A (KIR2DL5A Produkte)

Synonyme: CD158F antikoerper, KIR2DL5 antikoerper, KIR2DL5.1 antikoerper, KIR2DL5.3 antikoerper, KIR2DL5B antikoerper, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A antikoerper, KIR2DL5A antikoerper

Hintergrund: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3
Protein Interaction Partner: PTPN6, PTPN11,
Protein Size: 375

Molekulargewicht: 41 kDa

Gen-ID: 57292

NCBI Accession: NM_020535, NP_065396

UniProt: Q8N109