SYT1 Antikörper

Produktnummer ABIN272235

Produktdetails anti-SYT1 Antikörper

Target: SYT1 (Synaptotagmin I (SYT1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of SYT protein. (region surrounding Ala7)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SYT1

Target: SYT1 (Synaptotagmin I (SYT1))

Andere Bezeichnung: Synaptotagmin-1 (SYT1 Produkte)

Synonyme: P65 antikoerper, SVP65 antikoerper, SYT antikoerper, CG3139 antikoerper, D. Syt I antikoerper, DSYT antikoerper, DSYT2 antikoerper, DSypt antikoerper, DSyt antikoerper, Dmel\\CG3139 antikoerper, Droso1 antikoerper, Dsyt2 antikoerper, SYT I antikoerper, SYT1 antikoerper, Syt antikoerper, Syt 1 antikoerper, Syt I antikoerper, Syt-1 antikoerper, SytI antikoerper, dSYT antikoerper, dsyt1 antikoerper, dsytI antikoerper, l(2)23AB1 antikoerper, l(2)23Ba antikoerper, l(2)k05909 antikoerper, syt antikoerper, syt 1 antikoerper, syt I antikoerper, syt-1 antikoerper, syt1 antikoerper, sytI antikoerper, AW124717 antikoerper, G630098F17Rik antikoerper, Syti antikoerper, GB20036 antikoerper, DKFZP459P193 antikoerper, svp65 antikoerper, p65 antikoerper, wu:fj41c01 antikoerper, wu:fk56d05 antikoerper, zgc:92899 antikoerper, synaptotagmin 1 antikoerper, Synaptotagmin 1 antikoerper, synaptotagmin I antikoerper, synaptotagmin-1 antikoerper, synaptotagmin, p65 antikoerper, synaptotagmin Ia antikoerper, synaptotagmin 1 L homeolog antikoerper, SYT1 antikoerper, Syt1 antikoerper, Tsp_06980 antikoerper, Tsp_08220 antikoerper, syt1 antikoerper, LOC100533340 antikoerper, syt1a antikoerper, syt1.L antikoerper

Hintergrund: The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x,18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2, both fusions result in the production of transcriptional activators. SYT-SSX chimeras are detected in most synovial sarcomas. Synovial sarcomas are responsible for up to 10 % of soft issue sarcomas and are histologically characterized as either biphasic or monophasic.Genetic analysis indicates that biphasic synovial sarcomas contain SYT-SSX1 fusions, whereas SYT-SSX2 fusions are found in monophasic synovial sarcomas, providing additional distinguishing characterization of these subtypes.Synonyms: SVP65, SYT, SYT1, Synaptotagmin I, Synaptotagmin1, SytI, p65

Molekulargewicht: approx. 45 kDa

Gen-ID: 6857

NCBI Accession: NP_001129277

UniProt: P21579

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport