GIT2 Antikörper

Produktnummer ABIN272229

Produktdetails anti-GIT2 Antikörper

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GIT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of GIT2 protein. (region surrounding Asp391)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Andere Bezeichnung: GIT2 (GIT2 Produkte)

Synonyme: CAT-2 antikoerper, CAT2 antikoerper, cat-2 antikoerper, xgit2 antikoerper, git2 antikoerper, si:dkey-234h16.4 antikoerper, 1500036H07Rik antikoerper, 5830420E16Rik antikoerper, 6430510B20Rik antikoerper, 9630056M03Rik antikoerper, B230104M05Rik antikoerper, mKIAA0148 antikoerper, zgc:158416 antikoerper, GIT ArfGAP 2 antikoerper, G protein-coupled receptor kinase interacting ArfGAP 2 antikoerper, G protein-coupled receptor kinase interacting ArfGAP 2a antikoerper, G protein-coupled receptor kinase-interactor 2 antikoerper, G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog antikoerper, G protein-coupled receptor kinase interacting ArfGAP 2b antikoerper, GIT2 antikoerper, git2 antikoerper, git2a antikoerper, Git2 antikoerper, git2.L antikoerper, git2b antikoerper

Hintergrund: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of β2-adrenergic receptor, thus reducing β2-adrenergic receptor signaling.Synonyms: ARF GTPase-activating protein GIT2, CAT2, Cool-interacting tyrosine-phosphorylated protein 2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, KIAA0148

Molekulargewicht: approx. 84 kDa

Gen-ID: 9815

NCBI Accession: NP_001128685

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling