Tyrosine Hydroxylase Antikörper

Produktnummer ABIN271919

Produktdetails anti-Tyrosine Hydroxylase Antikörper

Target: Tyrosine Hydroxylase (TH)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tyrosine Hydroxylase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Tyrosine Hydroxylase protein. (region surrounding Gln25)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Andere Bezeichnung: Tyrosine 3-Monooxygenase (TH) (TH Produkte)

Synonyme: DYT14 antikoerper, DYT5b antikoerper, TYH antikoerper, The antikoerper, CG10118 antikoerper, DH65B antikoerper, DTH antikoerper, Dmel\\CG10118 antikoerper, Pale antikoerper, Ple antikoerper, TH antikoerper, Th antikoerper, VII antikoerper, dTH1 antikoerper, dTH65B antikoerper, pale/ple antikoerper, th antikoerper, dyt14 antikoerper, dyt5b antikoerper, tyh antikoerper, tyrosine hydroxylase antikoerper, pale antikoerper, tyrosine 3-monooxygenase antikoerper, tyrosine hydroxylase S homeolog antikoerper, TH antikoerper, Th antikoerper, ple antikoerper, th antikoerper, th.S antikoerper, LOC100008895 antikoerper

Hintergrund: The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.Synonyms: TYH, Tyrosine 3-hydroxylase

Molekulargewicht: approx. 58 kDa

Gen-ID: 7054

NCBI Accession: NP_000351

UniProt: P07101

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour